Gz signaling: emerging divergence from Gi signaling

lvement of the Gi-Coupled Signaling Pathway

Downlo ression of genes that encode oxytocin (OXT) and vasopressin (AVP) and their cognate receptors in normal seased prostates are only partially characterized. Reverse transcription and PCR were used to examine the sion of these genes in normal prostate epithelial and stromal cell lines, k-ras–transformed prostate epithel lines, and in four prostate cancer cell lines. Secreted and cell-associ...

Divergence and Identity - Signaling 1 From Whom Do People Diverge ? Out - Group Similarity , Identity - Signaling , and Divergence

TLR signaling: an emerging bridge from innate immunity to atherogenesis.

Chronic inflammation and disordered lipid metabolism represent hallmarks of atherosclerosis. Considerable evidence suggests that innate immune defense mechanisms might interact with proinflammatory pathways and contribute to development of arterial plaques. The preponderance of such evidence has been indirect clinical and epidemiologic studies, with some support from experimental animal models ...

Controlling signaling with a specifically designed Gi-coupled receptor.

We are developing a system to control G protein signaling in vivo to regulate a broad range of physiologic responses. Our system utilizes G protein-coupled peptide receptors engineered to respond exclusively to synthetic small molecule ligands and not to their natural ligand(s). These engineered receptors are designated RASSLs (receptor activated solely by a synthetic ligand). We have made two ...

Gi-biased β2AR signaling links GRK2 upregulation to heart failure.

RATIONALE Phosphorylation of β(2)-adrenergic receptor (β(2)AR) by a family of serine/threonine kinases known as G protein-coupled receptor kinase (GRK) and protein kinase A (PKA) is a critical determinant of cardiac function. Upregulation of G protein-coupled receptor kinase 2 (GRK2) is a well-established causal factor of heart failure, but the underlying mechanism is poorly understood. OBJEC...